Evidence map›Paper›PMID 41379612›Full record

ArticleACS nano2026

Mechanisms of Adeno-Associated Virus Serotype 9 Vector Characterization and Quality Control through Solid-State Nanopores.

Navod Thyashan, Janeesha Manawasinghe, Chaoming Gu, Santosh Khatri, Christopher Nelson, Merve Emecen Sanli, Steven J Gray, Sangyoup Lee, Prashanta Dutta, George Alexandrakis and 1 more

Abstract read
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mislabel Identification Using Transfer Learning-Based Ensemble Method.IEEE access : practical innovations, open solutions · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Navod ThyashanDepartment of Mechanical Engineering, Southern Methodist University, Dallas, Texas 75205, United States.
Janeesha ManawasingheDepartment of Mechanical Engineering, Southern Methodist University, Dallas, Texas 75205, United States.
Chaoming GuDepartment of Mechanical Engineering, Southern Methodist University, Dallas, Texas 75205, United States.
Santosh KhatriDepartment of Mechanical Engineering, Southern Methodist University, Dallas, Texas 75205, United States.
Christopher NelsonCenter for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States.
Merve Emecen SanliDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Steven J GrayDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Sangyoup LeeBionic Research Center, Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.ORCID 0000-0002-7961-3904
Prashanta DuttaSchool of Mechanical & Materials Engineering, Washington State University, Pullman, Washington 99164, United States.
George AlexandrakisDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas 76019, United States.ORCID 0000-0002-7046-1924
Min Jun KimDepartment of Mechanical Engineering, Southern Methodist University, Dallas, Texas 75205, United States.ORCID 0000-0002-0819-1644

Funding

Multimodal Label-Free Nanosensor for Single Virus Characterization and Content AnalysisR01GM149949 · NIGMS · SOUTHERN METHODIST UNIVERSITY · PI MinJun Kim · 2023 to 2026
$1.7M
NIGMS NIH HHS R01 GM149949
6 · The paper itself

Abstract

Adeno-associated virus (AAV) vectors are excellent gene-delivery carriers in gene therapy; however, improperly packaged capsids produced during manufacturing can reduce potency and raise safety concerns. We introduce a machine-learning-assisted, low-cost, label-free nanopore sensing platform with single-particle resolution to enhance AAV quality control. Using solid-state nanopore (SSN) devices on Si

Indexed as

DependovirusGenetic VectorsNanoporesCapsidHumansHydrogen-Ion ConcentrationQuality ControlSerogroupAAV vector quality controlbuffer-specific filtrationchemically tuned poresgene delivery vectorssingle-molecule sensingsolid-state nanoporesunsupervised learning

Identifiers

PMID41379612
PMCPMC13156842

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.