Evidence map›Paper›PMID 41379610›Full record

ArticleEmerging infectious diseases2025

Two Independent Acquisitions of Multidrug Resistance Gene lsaC in Streptococcus pneumoniae Serotype 20 Multilocus Sequence Type 1257.

Bernard Beall, Wuling Lin, Zhongya Li, Theresa Tran, Benjamin J Metcalf, Bridget J Anderson, Keipp H Talbot, Lesley McGee, Sopio Chochua

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bernard Beall
Wuling Lin
Zhongya Li
Theresa Tran
Benjamin J Metcalf
Bridget J Anderson
Keipp H Talbot
Lesley McGee
Sopio Chochua

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among >25,000 invasive pneumococcal disease isolates recovered in US locations during 2015-early 2024 through population-based surveillance, we detected 17 case isolates carrying the lsaC gene, which has been shown to confer resistance to clindamycin in group B Streptococcus. Sixteen isolates carried the mef, msrD, tetM, and lsaC genes on a 29-kb mobile element acquired through an interspecies recombination event and were intermediately clindamycin resistant. One isolate acquired a 62-kb mobile element containing the ermB, tetM, and lsaC genes through a transposition event. All 17 cases were in adults, including 4 adults experiencing homelessness and 9 with substance abuse problems. All 17 lsaC-positive isolates shared a 5.2-kb lsaC-containing element precisely integrated within the conserved oriT site of their respective mobile element. Those 17 lsaC-positive strains were all serotype 20, multilocus sequence type 1257, and were recovered recently (2021-2024); isolates 1-16 represented emergent disease clusters in New York and Connecticut.

Indexed as

Bacterial ProteinsDrug Resistance, Multiple, BacterialPneumococcal InfectionsStreptococcus pneumoniaeAdultAnti-Bacterial AgentsFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedMultilocus Sequence TypingSerogroupAnti-Bacterial AgentsBacterial Proteinsantimicrobial drugsantimicrobial resistancebacteriaclindamycin resistancepneumococcal lineageStreptococcus pneumoniaeUnited States

Identifiers

PMID41379610
PMCPMC12704531

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.