Evidence map›Paper›PMID 41379300›Full record

ArticleStem cell reviews and reports2026

Generation of iPSC-Derived iNKT Cells with Pro-Hematopoietic Activity.

Akhilesh Kumar, Sarah Ferguson, Saritha S D'Souza, Nikhila S Bharadwaj, Mathew Raymond, Jenny E Gumperz, Igor I Slukvin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akhilesh Kumar *Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53712, USA.
Sarah Ferguson *Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53706, USA.
Saritha S D'Souza *Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53712, USA.
Nikhila S BharadwajDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53706, USA.
Mathew RaymondWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53712, USA.
Jenny E GumperzDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53706, USA.
Igor I SlukvinWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53712, USA. islukvin@wisc.edu.

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
Development of iPSC-derived iNKT cells to promote hematopoietic engraftmentR21AI159042 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GUMPERZ, JENNY E., SLUKVIN, IGOR I. · 2022 to 2023
$428k
NCRR NIH HHS P51 RR000167NIAID NIH HHS R21 AI159042NIDDK NIH HHS R21AI159042NIH HHS P51 OD011106NIH Office of the Director P51OD011106
6 · The paper itself

Abstract

Human invariant natural killer T (iNKT) cells are a conserved population of innate-like T cells that are activated by glycolipid antigens. In addition to their well-known role in anti-tumor function, iNKT cells are also involved in regulating and maintaining hematopoiesis in the bone marrow. Here, we present the reprogramming of human CD4

Indexed as

HematopoiesisInduced Pluripotent Stem CellsNatural Killer T-CellsAntigens, CD1dAntigens, CD34Cell DifferentiationCells, CulturedCellular ReprogrammingCytokinesGalactosylceramidesHumansAntigens, CD1dAntigens, CD34CytokinesGalactosylceramidesHematopoiesisInduced pluripotent stem cellsiNKT cellsMyeloid progenitorsReprogramming

Identifiers

PMID41379300
PMCPMC12858510

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.