ArticleIrish journal of medical science2026
Neuroprotective effect of low-intensity ultrasound against diabetic neuropathy.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
aimTo investigate the possible neuroprotective effect of low-intensity ultrasound (US) application against diabetic neuropathy.
methodsAdult male wistar rats were randomly divided into three groups as control, untreated diabetic and US-treated diabetic. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg/kg) to the rats and verified by the presence of hyperglycemia (> 250 mg/dl). US was applied to sciatic nerve at a power density of 1.5 W/cm2 and a frequency of 1 MHz for 3 min/day for 5 weeks over a 5 cm2 skin surface. Blood glucose, insulin and HbA1c levels were measured. Nociceptive hot plate test and electrophysiological measurements were performed. Oxidative stress and inflammation markers were also examined.
resultsDiabetes led to increases in blood glucose, HgA1C, nociceptive response times, oxidative stress and neuroinflammation, but decreases in insulin and nerve conduction velocity. With the applied US treatment, these values indicative of diabetic neuropathy consistently approached those of healthy controls.
conclusionLow-intensity ultrasound treatment of sciatic nerve appears to be neuroprotective in diabetic neuropathy as it effectively alleviates the neurophysiological and inflammatory changes associated with the glucose irregularity.
Indexed as
Identifiers
41379270What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.