Evidence map›Paper›PMID 41379260›Full record

ArticleAnnals of surgical oncology2026

Risk Factors for Recurrence of Non-Small-Cell Lung Cancer After Anatomical Segmentectomy.

Alexia Christina Vakouftsi, Constantine Antonopoulos, Dimitrios Apostolou, Kostantinos Vachlas, Eleni Psychogiou, Charalambos Zisis

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Alexia Christina VakouftsiDepartment of Thoracic Surgery, Chest Disease Hospital Sotiria, Athens, Greece. alina.vakouftsi@gmail.com.
Constantine Antonopoulos1st Department of Vascular Surgery, Medical School, University of Athens, Attikon Hospital, Athens, Greece.
Dimitrios ApostolouDepartment of Thoracic Surgery, Chest Disease Hospital Sotiria, Athens, Greece.
Kostantinos VachlasDepartment of Thoracic Surgery, Chest Disease Hospital Sotiria, Athens, Greece.
Eleni PsychogiouDepartment of Pathology, Chest Disease Hospital Sotiria, Athens, Greece.
Charalambos ZisisDepartment of Thoracic Surgery, Chest Disease Hospital Sotiria, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to identify prognostic factors associated with recurrence after anatomical segmentectomy in patients with clinical stage IA1 and IA2 non-small-cell lung cancer (NSCLC).

methodsAll patients who underwent anatomical segmentectomy for clinical stage IA1 and IA2 NSCLC between January 2018 and January 2020 were included. Recurrence was histologically confirmed, with recurrent tumors presenting histopathological features identical to the primary lung cancer. Baseline clinical and pathological characteristics of patients with and without recurrence were compared using inferential statistical methods. Kaplan-Meier and Cox regression analyses evaluated significant predictors of recurrence over time.

resultsA total of 180 patients were retrospectively analyzed (mean age 70.4 ± 7.5 years; 63.9% males; mean follow-up 3.1 ± 0.9 years). Recurrence occurred in 18 patients (10%). Logistic regression analysis indicated that recurrence was 5.1 times more prevalent in patients with tumor size ≥ 1.5 cm than in those with tumor size  < 1.5 cm (odds ratio [OR] 5.1; 95% confidence interval [CI] 1.4-18.4, p = 0.01) and 2.9 times more prevalent in patients with pathological upstaging than in those without (OR 2.9; 95% CI 1.0-8.2, p = 0.04). Kaplan-Meier analysis revealed significant differences in recurrence-free estimates between patients with solid tumors ≥ 1.5 cm and those < 1.5 cm (p < 0.01) and between those with and without pathological upstaging (p = 0.05).

conclusionsRecurrence after anatomical segmentectomy for stage IA1 and IA2 NSCLC is significantly influenced by tumor size and pathological upstaging, underscoring the importance of tailored surgical strategies and meticulous pathological assessment to optimize long-term outcomes and reduce recurrence risk.

Indexed as

Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellLung NeoplasmsNeoplasm Recurrence, LocalPneumonectomyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesRisk FactorsSurvival RateAnatomical segmentectomyNSCLCPrognostic factorsRecurrence

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.