ArticleLasers in medical science2025
Dose-dependent effects of yellow laser irradiation on Viability, apoptosis, and ROS generation in cell lines from breast cancer.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is challenging to find effective breast cancer treatments as this disease is highly varied. But photobiomodulation therapy (PBMT) has shown promising results, specifically with the usage of yellow light. Even so, much work is still needed to understand its effect in cancer treatment.
objectiveThe aim is to determine the effect of 589 nm yellow laser light (5-20 J/cm²) at various dosages on cellular activities like metabolism, cell death (apoptosis), and reactive oxygen species (ROS) production, focusing on MCF-7 (ER-positive) and MDA-MB-231 (triple-negative) human breast cancer cells. This is expected to explain the drivers of photobiomodulation.
methodsThe MDA-MB-231 and MCF-7 breast cancer cells are exposed continuously to yellow light at 5, 10, 20 J/cm
resultsThe dosage-based yellow light exposure substantially decreased metabolic activity and boosted cell death (apoptosis) in both breast cancer cells, more so in the MCF-7 cells than the MDA-MB-231 cells. After exposure, the ROS levels particularly for the MCF-7 cells rose substantially, suggesting the major role of oxidative stress.
conclusionYellow laser exposure triggers targeted cell death and cytotoxic effects in breast cancer cells, especially in ER-positive MCF-7 cells. The findings suggest that yellow laser PBMT is promising as a treatment approach for certain breast cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.