ReviewCell biology and toxicology2025
Emerging role of PANoptosis in pathogen infection and systemic diseases.
Review in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Recent advances in PANoptosis research in kidney disease: mechanistic networks, pathological roles, and potential intervention strategies.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
ANoptosis represents a unique form of programmed cell death that amalgamates the core characteristics of pyroptosis, apoptosis, and necroptosis, yet it constitutes a distinct pathway beyond the scope of any single one of them. During pathogen infection, PANoptosis is regulated by multi-protein complexes called PANoptosomes, which sense specific stimuli, including viral, bacterial, or fungal components, ultimately resulting in PANoptosis. This process contributes to pathogen clearance as well as excessive inflammatory response. Additionally, in some diseases such as renal damage, myocardial disease, nervous system diseases, and various cancers, PANoptosis influences disease occurrence, progression, and treatment outcomes. Targeting PANoptosis represents a promising way to enhance immune responses and achieve disease treatment in systemic disorder. This review synthesizes the current state of knowledge regarding the molecular mechanisms underlying PANoptosis in pathogen infection and systemic diseases, highlighting its role in pathological processes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.