LdEP01, the first characterized Lycorma delicatula salivary effector protein modulates plant defenses.

Alexandrea G Smith, Julien G Levy, Flor E Acevedo, Cecilia Tamborindeguy

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Alexandrea G SmithDepartment of Entomology, Texas A&M University, College Station, TX, 77843, USA.

Julien G LevyDepartment of Horticultural Sciences, Texas A&M University, College Station, TX, 77843, USA.

Flor E AcevedoDepartment of Entomology, Penn State University, University Park, PA, 16802, USA.

Cecilia TamborindeguyDepartment of Entomology, Texas A&M University, College Station, TX, 77843, USA. ctamborindeguy@ag.tamu.edu.ORCID http://orcid.org/0000-0002-0933-5785

Funding

National Institute of Food and Agriculture McIntire Stennis project 8102-0 under the Accession # 7005263

6 · The paper itself

Abstract

backgroundThe spotted lanternfly (SLF), Lycorma delicatula, is a polyphagous invasive species in the United States known for causing significant damage to grapevines. This phloem-feeding insect secretes saliva containing effector proteins at the time of feeding, allowing for the ingestion of the phloem’s nutrients. The mechanisms that SLF uses to modulate plant defenses and feed efficiently remain unknown and understudied. Methods and Results: We identified LdEP01, an SLF predicted secreted effector protein with a FK506 binding protein (FKBP)-type domain and two EF-hand Ca2+ binding domains. LdEP01 is highly expressed in the salivary glands compared to the SLF’s full body. LdEP01 modulates plant defenses by suppressing cytosolic calcium accumulation and suppressing hypersensitive response (HR). Functional analysis confirmed that LdEP01 binds to calcium but does not undergo conformational change when bound to calcium. Conclusions: These findings suggest that LdEP01 plays a crucial role in modulating plant defenses, allowing SLF to feed efficiently on plants.

Indexed as

HemipteraInsect ProteinsPlant Defense Against HerbivorySalivary Proteins and PeptidesAnimalsCalciumSalivary GlandsCalciumInsect ProteinsSalivary Proteins and PeptidesCalcium signalingHemipteraHerbivore offenseSalivary proteinSpotted lanternfly

Identifiers

PMID41379233

DOI10.1007/s11033-025-11288-3

PMCPMC12698798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.