Evidence map›Paper›PMID 41379122›Full record

ReviewRadiologie (Heidelberg, Germany)2026

[Overview of immune checkpoint inhibitor therapy : What the radiologist should know].

Oliver Sedlaczek, Heinz-Peter Schlemmer

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Radiologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Oliver SedlaczekForschungsschwerpunkt Bildgebung und Radioonkologie, Abteilung Radiologie - E010, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland. o.sedlaczek@dkfz-heidelberg.de.
Heinz-Peter SchlemmerForschungsschwerpunkt Bildgebung und Radioonkologie, Abteilung Radiologie - E010, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

clinical issueIn recent decades, oncology has been fundamentally transformed by immune checkpoint inhibitors (ICIs). By blocking inhibitory molecules that normally inhibit T cell activation, they reactivate the body's immune defenses against tumors. TREATMENT INNOVATIONS: ICIs have established themselves in numerous tumor types-from melanomas to lung and kidney carcinomas to tumor entities defined essentially by high mutational burden-they offer significant survival benefits. DIAGNOSTICS: Radiology plays a central role in the management of these therapies, as phenomena such as pseudoprogression challenge the classic RECIST (response evaluation criteria in solid tumors) system, and early detection of immune-mediated side effects often precedes clinical manifestation in imaging. ASSESSMENT: The growing complexity of therapy requires radiologists to possess precise image interpretation, interdisciplinary collaboration, and knowledge of immunological principles, thus, enabling an improved prognosis for many tumor types.

Indexed as

Immune Checkpoint InhibitorsNeoplasmsHumansImmune Checkpoint InhibitorsCombination therapiesImmune-related adverse eventsPseudoprogressionRadiologic response assessmentTumor diseases

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.