Evidence map›Paper›PMID 41379102›Full record

ArticleACS applied materials & interfaces2025

Brush-like Polymer Surface on Silk Fibroin Films for Controlled Release of Local Anesthetics.

Sanyukta A Patil, Longtu Chen, Christopher Foster, Xinhao Lin, Yuhang Xiao, Xiuling Lu, Bin Feng, Courtney K Rowe, Kelly A Burke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanyukta A PatilDepartment of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.
Longtu ChenDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.
Christopher FosterDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut 06032, United States.
Xinhao LinDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, United States.
Yuhang XiaoDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.
Xiuling LuDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0002-1961-8156
Bin FengDepartment of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0001-9277-211X
Courtney K RoweDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut 06032, United States.
Kelly A BurkeDepartment of Chemical and Biomolecular Engineering, Polymer Science Program, Institute of Materials Science, Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, United States.ORCID 0000-0002-6741-0114

Funding

The Role of Lumbar Splanchnic Innervations in Visceral Nociception and PainR01DK120824 · NIDDK · UNIVERSITY OF CONNECTICUT STORRS · PI FENG, BIN · 2019 to 2023
$2.0M
Highly Tunable Brush-Like Polymer Architectures to Control Therapeutic Delivery and Cell-Material InteractionsR35GM146771 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI Kelly Anne Burke · 2022 to 2026
$2.0M
NIDDK NIH HHS R01 DK120824NIGMS NIH HHS R35 GM146771
6 · The paper itself

Abstract

Postsurgical pain management remains a persistent challenge for patients and healthcare providers. This work presents an implantable, degradable drug release platform based on silk biomaterials designed to be placed at a desired surgical site intraoperatively to release the local anesthetic bupivacaine in a sustained manner to prevent and treat postsurgical pain. Methacrylate monomers containing different pendant groups are used to generate brush-like polymers on silk fibroin films by surface-initiated reversible addition-fragmentation chain transfer polymerization. These brushes have side groups to control polymer hydrophilicity and facilitate drug attachment via a hydrolyzable tether. Spectroscopy and contact angle goniometry are used to characterize the chemical composition and hydrophobicity of the synthesized films at each synthetic step. In vitro culture and in vivo implant studies show no differences in biocompatibility compared with unmodified silk films. Bupivacaine can be continually released for at least 7 days. The amount of drug released in vitro is increased by increasing the hydrophilicity of the brush-like polymer, and the released anesthetic is effective at blocking the conduction of action potentials of C-fibers and Aδ-fibers ex vivo. These degradable films show promise as a platform to achieve controllable, continuous delivery of local anesthetics for pain control after surgery.

Indexed as

Anesthetics, LocalBupivacaineFibroinsPolymersAnimalsBiocompatible MaterialsDelayed-Action PreparationsDrug LiberationHumansHydrophobic and Hydrophilic InteractionsSurface PropertiesAnesthetics, LocalBiocompatible MaterialsBupivacaineDelayed-Action PreparationsFibroinsPolymersbrush-like polymersdrug releaselocal anestheticssilk fibroin

Identifiers

PMID41379102
PMCPMC12754761

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.