Evidence map›Paper›PMID 41379049›Full record

ArticleJACC. Case reports2026

Transcatheter Tricuspid Valve Replacement in a Heart Transplant Recipient.

Chloe Kharsa, Isadora Sande Mathias, Hassaan Bin Arshad, Catherine Teng, Nadeen N Faza, Stephen H Little, Marvin Atkins, Michael Reardon, Neal Kleiman, Sachin S Goel and 1 more

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chloe KharsaDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Isadora Sande MathiasDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Hassaan Bin ArshadDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Catherine TengDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Nadeen N FazaDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Stephen H LittleDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Marvin AtkinsDepartment of Cardiovascular Surgery, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Michael ReardonDepartment of Cardiovascular Surgery, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Neal KleimanDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Sachin S GoelDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA.
Joe AounDepartment of Cardiology, Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, USA. Electronic address: jaoun@houstonmethodist.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter tricuspid valve replacement (TTVR) is an emerging therapy for patients with severe tricuspid regurgitation (TR) who are often at prohibitive surgical risk. Orthotopic heart transplant recipients represent a particularly high-risk subgroup, frequently excluded from surgical intervention and underrepresented in clinical trials. CASE SUMMARY: We present one of the inaugural cases of TTVR using the EVOQUE valve system (Edwards Lifesciences) in an orthotopic heart transplant recipient with severe TR. The procedure was completed successfully without complications, yielding a well-seated prosthetic valve with no significant paravalvular leak and marked reduction in TR. The patient demonstrated significant clinical improvement, with functional status improving to NYHA functional class II. DISCUSSION: This case illustrates the feasibility and safety of the EVOQUE TTVR system in complex, high-risk patients. Importantly, it highlights the potential of this therapy in heart transplant recipients with torrential TR, a challenging population with limited therapeutic options. TAKE-HOME MESSAGES: The EVOQUE TTVR system appears to be a safe and feasible treatment option for orthotopic heart transplant recipients with severe or torrential TR, even in the setting of prior failed transcatheter edge-to-edge repair and challenging right heart anatomy. Multimodality imaging (transesophageal echocardiography, intracardiac echocardiography, and computed tomography) plays a critical role in procedural planning and guidance for complex TTVR cases, helping optimize outcomes in high-risk patients.

Indexed as

EVOQUE valveorthotopic heart transplanttranscatheter tricuspid valve replacementtricuspid regurgitation

Identifiers

PMID41379049
PMCPMC13100540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.