Evidence map›Paper›PMID 41378985›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2025

Cardiac implantable electronic device upgrades and downgrades: a Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Asia Pacific Heart Rhythm Association (APHRS), Canadian Heart Rhythm Society (CHRS), Heart Rhythm Society (HRS), and the Latin American Heart Rhythm Society (LAHRS).

Daniel Keene, Jens Cosedis Nielsen, Haran Burri, Carlos Alejandro Chavez-Gutierrez, Jean-Claude Deharo, Inga Drossart, James E Ip, Carsten W Israel, Jens Brock Johansen, Annamaria Kosztin and 11 more

Abstract readConsensus Statement
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Response to 'Upgrade procedures of pacemakers or implantable cardioverter-defibrillators require creative clinical decision making and careful planning that begins at the first implantation'.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Upgrade procedures of pacemakers or implantable cardioverter-defibrillators require creative clinical decision making and careful planning that begins at the first implantation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  3. Review
  4. Article
  5. Removal of tine-based leadless pacemakers: insights from a large multicentre experience.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  6. Review
  7. Review
  8. Adverse outcomes due to atrioventricular synchrony loss induced by temporary VVI pacing in patients with pre-existing DDD stimulation: insights from a device recall scenario.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Observational
  9. Controversy: in heart failure patients with a reduced ejection fraction and left bundle branch block, conduction system pacing can be a valid alternative to biventricular pacing-pro and contra.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Daniel KeeneNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-7472-7358
Jens Cosedis NielsenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-0631-0010
Haran BurriCardiac Pacing Unit, Cardiology Department, University Hospital of Geneva, Rue Gabrielle Perret Gentil 4, Geneva 14 1211, Switzerland.ORCID 0000-0002-4393-5338
Carlos Alejandro Chavez-GutierrezDepartment of Cardiology, National Medical Centre of the West, Guadalajara, Jalisco, Mexico.ORCID 0000-0001-8772-878X
Jean-Claude DeharoDepartment of Cardiology, L'hôpital de la Timone, Marseille 13005, France.ORCID 0000-0002-1534-3845
Inga DrossartEuropean Society of Cardiology, Sophia Antipolis, France.ORCID 0000-0002-6440-1642
James E IpWeill Cornell Medicine, New York Presbyterian Hospital, New York, NY, USA.ORCID 0000-0002-3461-505X
Carsten W IsraelDepartment of Medicine-Cardiology, Bethel-Clinic, Bielefeld, Germany.ORCID 0000-0003-1101-7556
Jens Brock JohansenDepartment of Cardiology, Odense University Hospital, Odense, Denmark.ORCID 0000-0001-7157-7948
Annamaria KosztinHeart and Vascular Center, Semmelweis University, Budapest, Hungary.ORCID 0000-0001-6647-2623
Chu-Pak LauQueen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-3526-8950
Shuli LevyDepartment of Geriatrics and General Internal Medicine, Imperial College Healthcare NHS Trust, London, UK.
Jaimie ManlucuDepartment of Cardiology, Western University/London Health Sciences Centre, London, Ontario, Canada.
Lina MarcantoniDepartment of Cardiology, Santa Maria Della Misericordia Hospital, Rovigo, Italy.ORCID 0000-0001-5854-9782
Margarida Pujol-LopezInstitut Clínic Cardiovascular (ICCV), Hospital Clínic, Universitat de Barcelona, Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.ORCID 0000-0002-4523-6469
Archana RaoDepartment of Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK.ORCID 0000-0002-3893-3944
Christoph StarckDepartment of Cardiothoracic and Vascular Surgery, German Heart Center of Charité, Berlin, Germany.ORCID 0000-0002-2753-1456
Jose Maria TolosanaInstitut Clínic Cardiovascular (ICCV), Hospital Clínic, Universitat de Barcelona, Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.ORCID 0000-0002-1215-3472
Lieselot Van ErvenDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3882-9941
Julia VoglerDepartment of Cardiology and Intensive Care Medicine, Asklepios Klinik St. Georg, Hamburg, Germany.ORCID 0000-0002-8386-9750
Nandita KazaNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-8725-5679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac implantable electronic device upgrade and downgrade procedures are increasingly being performed. Whilst the most appropriate guideline-recommended device may have been followed during a patient's initial procedure, the requirements of patients can change over time. This could be due to worsening of cardiac function due to detrimental effects of pacing itself or the diagnosis, development, or progression of another cardiac comorbidity. Device downgrades are also performed when a patient's clinical state changes and are often considered in patients with increased frailty and comorbidity. This clinical consensus statement aims to provide a framework for screening patients for device upgrade, pre-procedural planning considerations, available procedural strategies, namely a summary of techniques and approaches for vascular access, including ipsilateral and contralateral options, and a framework for when extraction to gain access may be appropriate. The document also provides advice on how to frame an ethical discussion with patients and carers on available options.

Indexed as

Arrhythmias, CardiacDefibrillators, ImplantableDevice RemovalPacemaker, ArtificialHumansRisk FactorsTreatment OutcomeCIED upgradeDowngrade

Identifiers

PMID41378985
PMCPMC12696876

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.