Evidence map›Paper›PMID 41378910›Full record

ArticlemBio2026

Combined inhibition of polyamine biosynthesis and uptake blocks

Arya Vindu, Brendan D Snarr, Chune Cao, Ronda J Rolfes, Otto Phanstiel, Michail S Lionakis, Thomas E Dever

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arya VinduDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Brendan D SnarrFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Chune CaoDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Ronda J RolfesDepartment of Biology, Georgetown University, Washington, DC, USA.ORCID 0000-0002-3851-1055
Otto PhanstielDepartment of Medical Education, College of Medicine, University of Central Florida, Orlando, Florida, USA.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-4994-9500
Thomas E DeverDivision of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0001-7120-9678

Funding

Phosphate and Inositol Pyrophosphate Metabolism in Candida albicansR15AI124160 · NIAID · GEORGETOWN UNIVERSITY · PI ROLFES, RONDA J · 2017 to 2023
$900k
NIAID NIH HHS R15 AI124160
6 · The paper itself

Abstract

Polyamines, small organic polycations, are essential for life, and cells maintain polyamines via synthesis and uptake. Recently, we identified Hol1 as the high-affinity polyamine transporter in

Indexed as

Candida albicansPolyaminesAnimalsBiological TransportCandidiasisDisease Models, AnimalFemaleFungal ProteinsGene DeletionHyphaeMembrane Transport ProteinsMiceOrnithine DecarboxylaseVirulenceFungal ProteinsMembrane Transport ProteinsOrnithine DecarboxylasePolyaminesCandida virulenceDFMOfungal inhibitionHol1polyaminepolyamine transportspermidineTrimer44NMe

Identifiers

PMID41378910
PMCPMC12802282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.