Evidence map›Paper›PMID 41378904›Full record

ArticlemAbs2026

Conformation-aware structure prediction of antigen-recognizing immune proteins.

Frédéric A Dreyer, Jan Ludwiczak, Karolis Martinkus, Brennan Abanades, Robert G Alberstein, Pan Kessel, Pranav Rao, Jae Hyeon Lee, Richard Bonneau, Andrew M Watkins and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Antibody-drug conjugate engineering: from design to efficacy and safety.Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Frédéric A DreyerPrescient Design, Genentech, South San Francisco, CA, USA.ORCID 0000-0002-0445-7863
Jan LudwiczakPrescient Design, Genentech, South San Francisco, CA, USA.
Karolis MartinkusPrescient Design, Genentech, South San Francisco, CA, USA.
Brennan AbanadesLarge Molecule Research, Roche, Penzberg, Germany.ORCID 0000-0001-8712-533X
Robert G AlbersteinPrescient Design, Genentech, South San Francisco, CA, USA.
Pan KesselPrescient Design, Genentech, South San Francisco, CA, USA.
Pranav RaoPrescient Design, Genentech, South San Francisco, CA, USA.
Jae Hyeon LeePrescient Design, Genentech, South San Francisco, CA, USA.
Richard BonneauPrescient Design, Genentech, South San Francisco, CA, USA.
Andrew M WatkinsPrescient Design, Genentech, South San Francisco, CA, USA.
Franziska SeegerPrescient Design, Genentech, South San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We introduce Ibex, a pan-immunoglobulin structure prediction model for antibodies, nanobodies, and T-cell receptors. Unlike previous approaches, Ibex explicitly distinguishes between bound and unbound protein conformations by training on labeled

Indexed as

AntigensReceptors, Antigen, T-CellSingle-Domain AntibodiesHumansModels, MolecularProtein ConformationAntigensReceptors, Antigen, T-CellSingle-Domain Antibodiesantibodyartificial intelligenceproteinstructural biologyStructure prediction

Identifiers

PMID41378904
PMCPMC12710905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.