Evidence map›Paper›PMID 41378873›Full record

ArticleSexually transmitted diseases2026

Herpes Simplex Virus Type 1 and Type 2 Western Blot Serology Test Results From 1999 to 2020 in a US Reference Laboratory.

Abir Hussein, Molly Fischer, Ethan Valinetz, Steven A Pergam, Stacy Selke, Gregory Pepper, Keith R Jerome, Alexander L Greninger, Anna Wald, Christine Johnston

Abstract read
In one paragraph

Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abir HusseinFrom the Division of Allergy and Infectious Diseases, Department of Medicine.
Molly FischerDepartment of Epidemiology, University of Washington, Seattle, WA.
Ethan ValinetzDeaconess Clinic, Evansville, IN.
Steven A PergamFrom the Division of Allergy and Infectious Diseases, Department of Medicine.
Stacy SelkeDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Gregory PepperDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Keith R JeromeFred Hutchinson Cancer Center.
Alexander L GreningerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Anna WaldFrom the Division of Allergy and Infectious Diseases, Department of Medicine.
Christine JohnstonFrom the Division of Allergy and Infectious Diseases, Department of Medicine.ORCID 0000-0002-3073-0843

Funding

THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 1991 to 2017
$34.3M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
NIAID NIH HHS P01 AI030731NIAID NIH HHS T32 AI007044NIAID NIH HHS T32 AI007140
6 · The paper itself

Abstract

We analyzed 162,397 deidentified HSV Western blot results performed at the University of Washington Virology Laboratory from 1999 to 2020. The seroprevalence of HSV-1 declined by 0.53% per year, whereas indeterminate HSV-1 results increased by 0.08% annually. Similarly, HSV-2 seroprevalence decreased by 0.72%, and indeterminate results increased by 0.16% each year.

Indexed as

Antibodies, ViralBlotting, WesternHerpes GenitalisHerpes SimplexHerpesvirus 1, HumanHerpesvirus 2, HumanAdolescentAdultFemaleHumansLaboratoriesMaleMiddle AgedSeroepidemiologic StudiesSerologic TestsUnited StatesAntibodies, Viral

Identifiers

PMID41378873
PMCPMC13450709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.