ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026
Impact of Diabetes Mellitus in Tuberculosis (TB) Patients on TB Transmission.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
backgroundDiabetes mellitus (DM) increases the risk of tuberculosis (TB) progression and poor treatment outcomes. Rising global DM prevalence presents an emerging threat to TB control. We sought to determine whether DM affects TB transmissibility.
methodsFrom 2009 to 2012, we enrolled 3109 microbiologically confirmed pulmonary TB patients and their 12 767 household contacts (HHCs) whom we followed for 1 year for the occurrence of TB infection as measured by a tuberculin skin test and for TB disease. We assessed the association between index patient DM and TB infection and disease occurrence in HHCs.
resultsThe DM status of index patients was not associated with TB infection among child HHCs (adjusted prevalence rate ratio [aPRR], 1.05; 95% CI: 0.78-1.42) or with incident TB infection at 6 months among HHCs uninfected at baseline (adjusted cumulative rate ratio [aCRR], 0.85; 95% CI: 0.66-1.09). Among the 12 442 HHCs without TB disease at baseline, 368 (3.0%) developed TB during the 12-month follow-up. HHCs exposed to an index TB patient with DM had a reduced incidence of TB disease (aCRR = 0.33, 95% CI: 0.13-0.85).
conclusionsIn this cohort study, diabetes mellitus in index patients did not increase the risk of TB infection among HHCs and was instead associated with a substantially lower risk of incident TB disease. These findings challenge the prevailing assumption that DM uniformly amplifies transmission due to its association with smear positivity and cavitary disease, suggesting that its influence on TB dynamics may be more complex than previously understood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.