ArticleJournal of the American Heart Association2025
Increasing Left Ventricular Mass and Death in Men and Women Investigated With Echocardiography.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07270367 (Finerenone and Cardiac Remodeling), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Finerenone and Cardiac Remodeling: A Randomized, Double- Blind, Placebo-Controlled Study to Evaluate The Effects of Finerenone on Ventricular Remodeling
Who cites it
2 citing papers in PubMed.
- Finding and Managing Heart Failure Earlier: Why Enhancing Primary Care Teams to Apply More Definitive Surveillance is the Solution.Cardiac failure review · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft ventricular hypertrophy (LVH) categories are based on left ventricular mass index (LVMi). This study aimed to generate and externally validate sex-stratified LVMi cutoffs according to incremental mortality risk.
methodsLVH information was determined on 155 668 men (aged 61.3±17.3 years) and 147 880 women (61.8±18.3 years) from the National Echocardiography Database of Australia. Sex-specific mild to severe thresholds of the increasing 5-year mortality rate based on LVMi increments were generated. These new thresholds were then validated in a US Medicare-linked echocardiographic database.
resultsIn the National Echocardiography Database, 36198 men (23.3%) and 38 898 women (26.3%) had LVH, with an actual 5-year mortality rate of 38.3% and 31.2%, respectively. The statistical threshold at which LVMi was associated with an increased mortality rate was lower than traditional criteria in both men (≥88 g/m
conclusionsA high proportion of men and women have LVMi levels associated with an elevated mortality risk, despite absence of LVH. Such individuals may benefit from more proactive recognition and clinical management.
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Registered trials
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