ArticleFrontiers in neuroscience2025
Disruption of global brain network topology in amnestic MCI: evidence from multimodal DTI and fMRI.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Investigation of the topological properties of brain structural and functional networks in patients with mild cognitive impairment.Quantitative imaging in medicine and surgery · 2026Article
- Moderating role of executive function in the relationship between specific white matter changes and long-term delayed recall in aMCI patients.Alzheimer's research & therapy · 2026Article
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10 authors.
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Abstract
Objective: This study aims to utilize multimodal neuroimaging techniques to simultaneously analyze global topological properties of white matter structural networks and resting-state functional networks in aMCI patients, comparing them with healthy controls. By conducting independent and integrative analyses of topological impairments in both networks, we seek to systematically characterize the multimodal network disruption patterns in aMCI. Methods: 45 aMCI patients and 42 healthy adults from the First Affiliated Hospital of Heilongjiang University of Chinese Medicine in Harbin, Heilongjiang Province, China, were enrolled. A case-control cross-sectional study was conducted. DTI and rs-fMRI data were collected for all participants. Global topological properties of structural and functional networks were constructed using PANDA and dpabi software and were calculated via graph-theoretical analysis in GRETNA software, followed by statistical comparisons between groups. Results: In patients with aMCI, the small-world (C Conclusion: We identified a "structure-function dissociation" in aMCI, where the structural network suffers from fragmentation and hub disruption, while the functional network compensates through rigid, hyper-localized reorganization with elevated local efficiency. This divergence reveals a core pathological mechanism of the disease.
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