Evidence map›Paper›PMID 41378329›Full record

ArticleWorld journal of gastroenterology2025

Transient elastography and fibrosis-4 index as predictors of hepatocellular carcinoma in hepatitis C virus patients with sustained virological response.

Paula G F da Silva, Juliana B P Barrocas, Hugo Perazzo, Livia Villela-Nogueira, Helena R Peixoto, Gustavo H S Pereira, Lailiane N P Braga, Miriam Chinzon, Joyce R L de Silva, Flávia F Fernandes and 1 more

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Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

11 authors.

Paula G F da SilvaDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital, Rio de Janeiro 21041020, Brazil.
Juliana B P BarrocasDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital, Rio de Janeiro 21041020, Brazil.
Hugo PerazzoEvandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro 21040360, Brazil.
Livia Villela-NogueiraSchool of Medicine, Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941617, Brazil.
Helena R PeixotoSchool of Medicine, Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941617, Brazil.
Gustavo H S PereiraDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital, Rio de Janeiro 21041020, Brazil.
Lailiane N P BragaDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital, Rio de Janeiro 21041020, Brazil.
Miriam ChinzonDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital, Rio de Janeiro 21041020, Brazil.
Joyce R L de SilvaDepartment of Gastroenterology and Hepatology, Bonsucesso Federal Hospital, Rio de Janeiro 21041020, Brazil.
Flávia F FernandesPedro Ernesto University Hospital, University of the State of Rio de Janeiro, Rio de Janeiro 20551030, Brazil.
Cristiane A Villela-NogueiraSchool of Medicine, Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941617, Brazil. crisvillelanog@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeople with compensated advanced chronic liver disease (cACLD) remain at high risk of hepatocellular carcinoma (HCC) even after hepatitis C virus (HCV) sustained virological response (HCV-SVR).

aimTo evaluate transient elastography and fibrosis-4 (FIB-4) index as prognostic markers for HCC after HCV-SVR.

methodsThis retrospective cohort study analyzed data from people with cALCD and HCV-SVR. cALCD was defined as baseline liver stiffness measurement (LSM) ≥ 10 kPa. The primary outcome was the occurrence of HCC. Data collected at baseline (pre-treatment) and 1 year after the end of treatment (1-year-EOT) of LSM, FIB-4 index, and laboratory results were analyzed. LSM and FIB-4 index were evaluated as independent predictors of HCC by a Cox regression analysis. Receiver operator characteristic curves, Kaplan-Meier curves, and Cox regression analysis were performed.

resultsTotal of 425 patients (65.2% female; mean age = 62 ± 10 years) were included. The median pre-treatment and 1-year-EOT LSM were respectively 15.0 kPa (interquartile range: 11.8-23.2) and 12 kPa (interquartile range: 7.9-19.9) (

conclusionIn cACLD-HCV SVR patients, pre-treatment or 1-year-EOT LSM ≥ 20 kPa and FIB-4 ≥ 3.25 but not their delta was associated with HCC. A single measure of LSM ≥ 20 kPa or FIB-4 ≥ 3.25, either pre-treatment or 1-year-EOT, would be necessary to predict the incidence of HCC in people with HCV-SVR.

Indexed as

Antiviral AgentsCarcinoma, HepatocellularElasticity Imaging TechniquesHepatitis C, ChronicLiver CirrhosisLiver NeoplasmsAgedFemaleHepacivirusHumansLiverMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesAntiviral AgentsFibrosis-4 index scoreHepatitis C virusHepatocellular carcinomaLiver stiffnessNoninvasive testsSustained virological response

Identifiers

PMID41378329
PMCPMC12686994

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