Evidence map›Paper›PMID 41378253›Full record

ReviewWorld journal of biological chemistry2025

Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma.

Enrique Oropeza-Martínez, Eva G Palacios Serrato, Sayra X Zamora-Salas, Norma A Lira-Rodríguez, Sianka'an Hz López-Mignon, Maximo B Martinez-Benitez, Angeles C Tecalco-Cruz

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Enrique Oropeza-MartínezPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.
Eva G Palacios SerratoPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.
Sayra X Zamora-SalasPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.
Norma A Lira-RodríguezPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.
Sianka'an Hz López-MignonPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.
Maximo B Martinez-BenitezPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico.
Angeles C Tecalco-CruzPosgrado en Ciencias Genómicas, Autonomous University of Mexico City, Mexico 03100, Ciudad de México, Mexico. angeles.tecalco@uacm.edu.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The canonical signaling of interferon gamma (IFN-γ) through the Janus kinase 1 and 2-signal transducer and activator of transcription 1 (STAT1) axis leads to the expression of several interferon-stimulated genes (ISGs), which have diverse effects depending on the cellular context. In glioblastoma, a highly aggressive primary brain tumor in adults, elements of IFN-γ canonical signaling are deregulated, resulting in the overexpression of STAT1-target ISGs associated with tumor progression. This mini-review highlights key ISGs, including

Indexed as

B7-H1 antigenGlioblastomaIndoleamine-2,3-dioxygenaseInterferon gammaInterferon regulatory factor 1Interferon-stimulated gene 15Interferon-stimulated genesJanus kinasesSignal transducer and activator of transcription 1Signal transduction

Identifiers

PMID41378253
PMCPMC12687043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.