ArticleFrontiers in pharmacology2025
Allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide alkaloids alleviate cellular stress by modulating calcium homeostasis and the MAPK and akt/GSK-3β/tau signaling pathways.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Comparative Analysis of Extracellular Vesicle-Like Particles From Different ProcessingFood science & nutrition · 2026Article
- Unlocking the Power of Plant-Derived Natural Products: Therapeutic Benefits for Cognitive Health and Neuropsychiatric Symptoms in Dementia-Related Diseases.Plants (Basel, Switzerland) · 2026Review
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Abstract
Introduction: Methods: The plant was collected, identified, and the GGAE was prepared by macerating dried, pulverized material in chloroform. The GGAE's neuroprotective properties were assessed using the rat pheochromocytoma (PC12) cell line. Intracellular calcium levels were analyzed via flow cytometry; gene expression of L-type voltage-gated calcium channel subtypes was evaluated with qRT-PCR; and the phosphorylation status of key proteins (p-ERK1/2, p-JNK, p-p38, p-Akt, p-GSK-3β, and p-Tau) was determined using Western blotting. The binding energies and contact residues of alkaloids (allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide) found in the GGAE were determined to target proteins (AKT1, CACNA1C, CACNA1D, ERK1/2, GSK3β, JNK, P38, and TAU). Results: The results suggest that the GGAE helps maintain intracellular calcium homeostasis and functions as an L-type Ca Discussion: These findings suggest that the GGAE exerts a comprehensive neuroprotective effect, positioning it as a promising therapeutic candidate for the treatment of NDs.
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