ReviewBiophysical reviews2025
Microscopy-based techniques for studying the material properties of biomolecular condensates in the cellular environment.
Review in Biophysical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Probing biomolecular condensates with a minimally perturbative experimental readout framework.The Biochemical journal · 2026Review
- Liquid-Liquid Phase Separation-Enhanced Multienzyme Catalysis: Mechanisms and Applications.ChemSusChem · 2026Review
- Physiological implications of phase separation in vesicle organization and trafficking.BMC biology · 2026Review
- Biophysics in Great Britain and Ireland.Biophysical reviews · 2025Article
- RNA-Protein Assemblies: A Review of Biophysical Principles and Coarse-Grained Modeling Approaches.Wiley interdisciplinary reviews. RNAReview
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Authors and funding
3 authors.
Funding
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Abstract
The material properties of biomolecular condensates, such as interfacial tension, viscoelasticity, stiffness, and molecular dynamics, are crucial for their biological functions in processes like signal transduction, stress response, and gene regulation. These properties influence both endogenous condensates, like the nucleolus and stress granules, and synthetic condensates engineered for potential drug delivery applications. In vitro studies, using purified components, provide controlled environments to explore the fundamental physics of phase separation, offering high precision in manipulating molecular components and conditions. However, cell-based characterisations are indispensable for understanding the physiological relevance of biomolecular condensates, accounting for molecular crowding, post-translational modifications, and interactions with cellular structures. Light-microscopy techniques offer the potential to bridge in vitro findings with
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