Evidence map›Paper›PMID 41378076›Full record

ArticleWorld journal of gastrointestinal pharmacology and therapeutics2025

Real-world effectiveness and safety of teduglutide in adult and pediatric patients with short bowel syndrome in Argentina.

Héctor Solar Muñiz, Adriana Fernández, Verónica Busoni, María Inés Martínez, Carolina Rumbo, Silvia De Barrio, Carola Saure, Martín Balacco, Martín Gonzalo Buncuga, Corina Dlugoszweski and 10 more

Abstract read
In one paragraph

Article in World journal of gastrointestinal pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Real-world effectiveness and safety of teduglutide in patients with short bowel syndrome.World journal of gastrointestinal pharmacology and therapeutics · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Héctor Solar MuñizDepartment of Nutritional Support, Rehabilitation and Intestinal Transplant, Fundación Favaloro, Buenos Aires C1093, Argentina.
Adriana FernándezFacultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata B1900, Buenos Aires, Argentina.
Verónica BusoniGastroenterology and Hepatology Unit, Department of Pediatrics, Hospital Italiano de Buenos Aires, Buenos Aires C1181, Argentina.
María Inés MartínezDepartment of Nutritional Support, Rehabilitation and Intestinal Transplant, Fundación Favaloro, Buenos Aires C1093, Argentina.
Carolina RumboDepartment of Nutritional Support, Rehabilitation and Intestinal Transplant, Fundación Favaloro, Buenos Aires C1093, Argentina.
Silvia De BarrioDepartment of Gastroenterology, Hospital Interzonal General de Agudos General José de San Martin, La Plata B1900, Buenos Aires, Argentina.
Carola SaureDepartment of Pediatric Nutrition, Hospital J. P. Garrahan, Buenos Aires C1245, Argentina.
Martín BalaccoDepartment of Pediatric Intensive Care, Hospital de Niños Santísima Trinidad de Córdoba, Cordoba X5000, Argentina.
Martín Gonzalo BuncugaDepartment of Internal Medicine, Clínica Delta de Rosario, Rosario S2000, Santa Fe, Argentina.
Corina DlugoszweskiDepartment of Pediatric Nutrition, Hospital Materno Infantil de Salta, Salta A4400, Argentina.
Alejandra ManzurDepartment of Internal Medicine, Clínica de Cuyo, Mendoza M5500, Argentina.
Lorena RudiDepartment of Pediatric Nutrition, Hospital Posadas, Buenos Aires B1684, Argentina.
María Dolores MatosoDepartment of Gastroenterology, Hospital Italiano de Buenos Aires, Buenos Aires C1181, Argentina.
Sandra CosentinoDepartment of Pediatric Nutrition, Clinica San Lucas, Neuquen Q8300, Argentina.
Federico UssherDepartment of Medical Affairs, Takeda Argentina SA, Buenos Aires C1429, Argentina.
Fernando ManzurDepartment of Medical Affairs, Takeda Argentina SA, Buenos Aires C1429, Argentina.
Julia DemarchiDepartment of Medical Affairs, Takeda Argentina SA, Buenos Aires C1429, Argentina.
Elisa MalaverDepartment of Medical Affairs, Takeda Argentina SA, Buenos Aires C1429, Argentina.
Laura BrionDepartment of Medical Affairs, Takeda Argentina SA, Buenos Aires C1429, Argentina.
Laura UngarDepartment of Medical Affairs, Takeda Argentina SA, Buenos Aires C1429, Argentina. laura.ungar@takeda.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApproval of teduglutide is an important addition to the limited treatment options for short bowel syndrome (SBS). However, real-world evidence on teduglutide therapy for SBS in Latin America is scarce.

aimTo investigate the effectiveness and safety of teduglutide in clinical practice in Argentina with a 24-week follow-up.

methodsThis non-interventional multicentre cohort study included consecutive patients (aged ≥ 1 years) with SBS who were dependent on parenteral support (PS) and received ≥ 1 dose of teduglutide according to currently approved indications.

resultsThe study population (

conclusionThis prospective real-world study demonstrated the effectiveness and safety of teduglutide in adult and pediatric patients with SBS in Argentina. The clinical response observed in both adults and pediatric patients was greater than that reported in phase 3 trials and was consistent with the results of other real-world studies.

Indexed as

Intestinal failureParenteral nutritionParenteral supportReal-worldShort bowel syndromeTeduglutideWeaning

Identifiers

PMID41378076
PMCPMC12687021

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.