ArticleWorld journal of gastrointestinal pharmacology and therapeutics2025
Trends in diverticular disease mortality among United States adults (1999-2020) by gender, race, and geographic region.
Article in World journal of gastrointestinal pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiverticular disease of the intestine is a major gastrointestinal cause of mortality in the United States and the world. It is one of the most common gastrointestinal conditions responsible for hospital admissions.
aimTo identify mortality trends of diverticular disease among adults in the United States, examining regional and demographic variations, as these have not been previously studied. These trends are highly beneficial to studying disease burden and vulnerable populations.
methodsDiverticular disease-related mortality data were extracted as age-adjusted mortality rates (AAMRs) from death certificate data of the CDC WONDER database using International Statistical Classification of Diseases and Related Health Problems-10
resultsBetween 1999 and 2020, a total of 114044 diverticular disease-related deaths were reported among adults ≥ 45 years of age. Our analysis reports progressive decline in mortality with AAMR decreasing from 6.7 in 1999 to 6.1 in 2003 [APC: -2.60; 95% confidence interval (CI): -3.79 to -0.33], after which it further declined to 3.6 in 2013 (APC: -5.16; 95%CI: -7.26 to -4.74), with a minimal decrease to 3.5 in 2020 (APC: -0.65; 95%CI: -1.87 to 1.51). Women had a higher AAMR (4.8) than men (3.8) throughout the study period. The racial analysis reported the highest overall AAMR in non-Hispanic (NH) Whites (4.7), followed by NH Black or African American (3.9), Hispanic or Latino (3.1), and Asian or Pacific Islander (1.5), with unreliable data for the American Indian or Alaska Native population. States in the top 90
conclusionAlthough the annual mortality of diverticular disease has decreased since 1999, there are certain demographic and regional disparities, with mortality rates higher in women, NH White and NH Black adults, Western regions, and nonmetropolitan areas. Further research is needed to identify factors responsible for these disparities and plan appropriate interventions.
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