Evidence map›Paper›PMID 41378049›Full record

ArticleTranslational cancer research2025

Neutrophil depletion dampens inflammation and enhances CD8

Maike Zheng, He Chang, Shuqin Li, Chaohong Wang, Sibo Long, Yongqiang Wang, Tongmei Zhang, Guirong Wang, Yu Wang, Yan Zhao

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Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Maike ZhengDepartment of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.ORCID https://orcid.org/0009-0009-3903-2433
He ChangNational Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Shuqin LiNational Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Chaohong WangDepartment of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Sibo LongDepartment of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Yongqiang WangNational Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Tongmei ZhangDepartment of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Guirong WangDepartment of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Yu WangDepartment of Clinical Laboratory Sciences, Yanjing Medical College, Capital Medical University, Beijing, China.
Yan ZhaoDepartment of Clinical Laboratory, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung cancer remains a leading cause of cancer-related mortality, with poor survival outcomes. Despite the widespread use of programmed cell death protein 1 (PD-1) blockade therapy, more than 70% of patients fail to benefit and might even develop adverse inflammatory responses. Clinical observations have shown that patients with high neutrophil levels experience worse outcomes following PD-1 blockade. However, the underlying mechanism remains elusive. This study aimed to investigate the impact of neutrophils on anti-PD-1 therapy in lung cancer. Methods: Clinical cohort analysis revealed that peripheral neutrophil levels correlated with survival and metastasis in non-small cell lung cancer (NSCLC) patients treated with PD-1 blockade. In this study, we established a subcutaneous Lewis lung carcinoma (LLC) mouse model, and depleted neutrophils by anti-Ly6G antibody with or without PD-1 blockade. Dynamic changes of peripheral immune cells (CD4 Results: Clinically, patients with high neutrophil counts exhibited significantly shorter progression-free survival (PFS) and overall survival (OS), and were more prone to distant organ metastases. In the mouse model, neutrophil depletion enhanced CD8 Conclusions: Our observation shows that high neutrophil levels in cancer patients are associated with poorer prognosis and increased risk of distant metastasis. Depletion of neutrophils reshapes the tumor immune microenvironment, wherein excessive inflammatory cytokines drive resistance to PD-1 antibody therapy.

Indexed as

CD8+ T cellinflammationLung cancerneutrophilprogrammed cell death protein 1 (PD-1)

Identifiers

PMID41378049
PMCPMC12686212

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