ArticleTranslational cancer research2025
PM2.5 promotes non-small cell lung cancer tumorigenesis by miR-21-5p targeting
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Fine particulate matter (PM2.5) is associated with increased risk of lung cancer. microRNAs (miRNAs) play an important role in a variety of cancers, including NSCLC. In NSCLC, existing literature has revealed upregulation of miR-21-5p. Nonetheless, the molecular mechanism of miR-21-5p in NSCLC development after PM2.5 exposure is not clear. This study aimed to investigate the role of miR-21-5p in NSCLC development after PM2.5 exposure and to elucidate the underlying molecular mechanisms. Methods: Expression of miR-21-5p, Results: miR-21-5p was up-regulated in NSCLC tumor tissues and cell lines. Also, PM2.5 exposure led to a higher level of miR-21-5p. The miR-21-5p mimic and inhibitor respectively promoted and decreased proliferation and migration/invasion of NSCLC cells. Tumor growth was reduced in miR-21-5p KO mice Conclusions: miR-21-5p could target
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