ArticleResearch square2025
Advancing Proton Therapy: Integration of Minibeam Spatial Fractionation and FLASH Dose Rates.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Proton minibeam radiation therapy (pMBRT) introduces spatial fractionation of dose distributions at submillimeter resolution, offering a promising approach to reducing normal tissue toxicity while maintaining effective tumor control. However, the high monitor unit (MU) requirements of multi-slit collimators (MSC) result in extended delivery times, posing a significant challenge. This study explores the feasibility of integrating pMBRT with ultra-high-dose-rates (UHDR) to overcome this limitation while leveraging potential biological synergies to enhance the therapeutic index and advance clinical applications. Methods: The study utilized the IBA Proteus Results: The study successfully demonstrated pMBRT dose distributions under FLASH dose rates, significantly reducing treatment times to 2.5 seconds compared to 3 minutes for clinical beams. The 10 cm collimator achieved higher peak-to-valley dose ratios (PVDRs) at 2 cm depth (4.36) than the 6.5 cm collimator (2.57), optimizing FLASH delivery conditions. Results highlight the potential to improve dose delivery efficiency while maintaining spatial resolution and dose modulation, supporting future clinical advancements. Conclusion: This study demonstrates the feasibility of integrating pMBRT with FLASH dose rates using a clinical proton therapy system. By addressing challenges associated with delivery times and leveraging the combined advantages of spatial fractionation and ultra-high-dose-rates, this work paves the way for the clinical translation of pMBRT with FLASH, offering innovative possibilities for treating challenging malignancies with high-dose precision therapy.
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