Evidence map›Paper›PMID 41377970›Full record

ArticleResearch square2025

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.

Evan Pepper-Tunick, Vivek Srinivas, Fred D Mast, Song Li, Sagan Russ, Weston Hanson, Amy D Zamora, Wei-Ju Wu, Matthew Silcocks, Dang Thi Minh Ha and 6 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Evan Pepper-TunickInstitute for Systems Biology, Seattle, WA, USA.
Vivek SrinivasInstitute for Systems Biology, Seattle, WA, USA.
Fred D MastSeattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-2177-6647
Song LiSeattle Children's Research Institute, Seattle, WA, USA.
Sagan RussInstitute for Systems Biology, Seattle, WA, USA.
Weston HansonInstitute for Systems Biology, Seattle, WA, USA.ORCID 0009-0009-2204-0816
Amy D ZamoraInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0001-8796-9292
Wei-Ju WuInstitute for Systems Biology, Seattle, WA, USA.
Matthew SilcocksDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.ORCID 0000-0002-1527-5168
Dang Thi Minh HaPham Ngoc Thach Hospital for TB and Lung Disease, District 5, Ho Chi Minh City, Vietnam.
Sarah J DunstanDepartment of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.ORCID 0000-0001-7873-933X
Thuong Nguyen Thuy ThuongOxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam.
Serdar TurkarslanInstitute for Systems Biology, Seattle, WA, USA.
John D AitchisonSeattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-9153-6497
Mario L Arrieta-OrtizInstitute for Systems Biology, Seattle, WA, USA.
Nitin S BaligaInstitute for Systems Biology, Seattle, WA, USA.

Funding

Systems Biology, Bioinformatics, & Data IntegrationU19AI162583 · NIAID · UNIVERSITY OF WASHINGTON · PI DUNSTAN, SARAH JANE · 2021 to 2025
$13.0M
A systems analysis of drug tolerance in Mycobacterium tuberculosisR01AI128215 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI Nitin S Baliga · 2017 to 2026
$8.8M
Site Specific Immunophenotyping Assays of COVID19 Patients to Align with NIAID National StudyR01AI141953 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2019 to 2023
$5.7M
Gates Foundation INV-009322NIAID NIH HHS R01 AI128215NIAID NIH HHS R01 AI141953NIAID NIH HHS U19 AI162583
6 · The paper itself

Abstract

The rapid emergence of multidrug-resistant

Identifiers

PMID41377970
PMCPMC12687858

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.