Observational studyFrontiers in endocrinology2025
Selected parameters of epidermal barrier in juveniles with type 1 diabetes correspond with the severity of diabetes - an observational study.
Observational study in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Beyond clinical closure: functional skin barrier recovery to prevent diabetic foot ulcer recurrence: a narrative review.Frontiers in endocrinology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Our study aimed to evaluate the epidermal barrier function in children with type 1 diabetes. To the author's knowledge, no studies have been conducted on epidermal barrier parameters, including TEWL and measurement of epidermal hydration, in children and adolescents with type 1 diabetes. Methods: One hundred sixty children and adolescents aged 6-18, 125 patients with type 1 diabetes, and 35 healthy volunteers participated in the study: a detailed clinical evaluation, transepidermal water loss (TEWL) measurement, and epidermal hydration (corneometry) were carried out. Results: Poor metabolic control in type 1 diabetes, higher HbA1c(%), and more frequent hyperglycemia impact TEWL and epidermis hydration. Also, the level of BF(%) correlated positively with TEWL. Conclusions: Extended supplementary tests - the assessment of TEWL and corneometry - could be included in the periodic examinations of children and adolescents with type 1 diabetes mellitus. Clinicians should always pay attention to dry skin in children with diabetes, and noninvasive examination (TEWL measurement and corneometry) may allow us to isolate a group at risk of neuropathy or the development of the diabetic foot. Further tests enabling detailed assessment of the usefulness of TEWL measurements and corneometry are needed.
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