Evidence map›Paper›PMID 41377903›Full record

ArticleIranian journal of medical sciences2025

Oxidative Stress Influences Exosome Biogenesis by Inducing Cellular Senescence in Uterine Adenocarcinoma Ishikawa Cells.

Fatemeh Sokouti Nasimi, Behrad Alimohammadzadeh, Amir Mehdizadeh, Dhafer A F Al-Koofee, Amin Tamadon, Mahdi Mahdipour, Reza Rahbarghazi

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In one paragraph

Article in Iranian journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fatemeh Sokouti NasimiStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Behrad AlimohammadzadehStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir MehdizadehHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Dhafer A F Al-KoofeeDepartment of Clinical Laboratory Science, Faculty of Pharmacy, University of Kufa, Najaf, Kufa 54003, Iraq.
Amin TamadonDepartment of Natural Sciences, West-Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Mahdi MahdipourStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza RahbarghaziStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The progression of life and cellular senescence can alter the physiological activity of every cell type. Here, the possible effect of oxidative stress on exosome (Exo) biogenesis was studied in endometrial adenocarcinoma Ishikawa cells. Methods: This Results: The expression of SA-β-gal confirmed the successful induction of aging in Ishikawa cells after 4 days (P=0.0286). DLS analysis indicated a slight increase and decrease in mean Exo size and zeta potential, respectively, in H Conclusion: Oxidative stress can influence Exo biogenesis and paracrine activity in endometrial tumor cells via the induction of cellular senescence.

Indexed as

AdenocarcinomaCellular SenescenceEndometrial NeoplasmsExosomesOxidative StressCell Line, TumorFemaleHumansHydrogen PeroxideHydrogen PeroxideBiogenesisCellular senescenceExtracellular vesiclesParacrine communicationUterine neoplasms

Identifiers

PMID41377903
PMCPMC12686952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.