Report of a case of nasal-type extranodal NK/T-cell lymphoma with ciliary body involvement and literature review of interleukin-10 and interleukin-6 in intraocular T-cell lymphoma.

Madeline S Louie, Nathan A Brice, Edmund Tsui, Judy L Chen, Colin A McCannel

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Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Madeline S LouieDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza Driveway, Los Angeles, CA, 90095, USA.

Nathan A BriceDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza Driveway, Los Angeles, CA, 90095, USA.

Edmund TsuiDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza Driveway, Los Angeles, CA, 90095, USA.

Judy L ChenDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza Driveway, Los Angeles, CA, 90095, USA.

Colin A McCannelDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza Driveway, Los Angeles, CA, 90095, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To present a presumed case of NK/T-cell lymphoma with ciliary body involvement, emphasizing key clinical findings and diagnostic testing that facilitated differentiation from anterior uveitis. Methods: Retrospective case report and review of the literature. Results: A 47-year-old man with a history of nasal-type extranodal NK/T-cell lymphoma (ENKL) presented with cloudy vision in the left eye and was initially diagnosed with anterior uveitis. Work-up initially included aqueous interleukin-10 (IL-10) and interleukin-6 (IL-6) ratio determination, and later B-scan and ultrasound biomicroscopy (UBM). The IL-10/IL-6 ratio was less than 1, but ultrasound imaging revealed peripheral subretinal fluid and ciliary body thickening. The patient underwent five cycles of intravitreal methotrexate for presumed uveal lymphoma involving the ciliary body with pseudo-keratic precipitates before a nasal biopsy confirmed recurrent ENKL. A review of the literature regarding IL-10/IL-6 ratios showed that 71 % of published cases of intraocular T-cell lymphoma had ratios less than 1. Conclusion: ENKL, nasal type, is an aggressive and uncommon disease, and its ocular involvement, though infrequent, can resemble anterior uveitis. The IL-10/IL-6 ratio is of limited value in the diagnosis of T-cell lymphoma affecting intraocular structures. This case highlights the critical role of UBM in identifying ciliary body involvement of intraocular malignancies.

Indexed as

Ciliary bodyExtranodal NK/T-cell lymphomaInterleukin-10Interleukin-6Intraocular lymphomaUltrasound biomicroscopy

Identifiers

PMID41377857

DOI10.1016/j.ajoc.2025.102483

PMCPMC12686643

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