ArticleFrontiers in medicine2025
Effects of different anesthetics on remifentanil-induced postinfusion hyperalgesia in patients undergoing percutaneous endoscopic interlaminar discectomy: a randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Continuous infusion of remifentanil during anesthesia potentially leads to remifentanil-induced postinfusion hyperalgesia (RPH), which may be regulated by anesthesia maintenance drugs. In this study, we investigated the effects of different anesthetics (remimazolam, propofol or sevoflurane) on RPH. Methods: One hundred and eleven patients who underwent percutaneous endoscopic interlaminar discectomy (PEID) under remifentanil-based anesthesia were randomized to one of three groups as follows: anesthesia maintenance with remimazolam (Group R), propofol (Group P) or sevoflurane (Group S). The mechanical pain thresholds of the forearm and incision area were measured using Von Frey filaments preoperatively and 24 h after surgery. Pain intensity, sufentanil consumption, side effects, and comfort and satisfaction were recorded for 24 h after surgery. Results: At 24 h after surgery, the mechanical pain thresholds around the skin incision were significantly greater in Group R [77.6 (19.7) vs. 63.7 (11.0) g, Conclusion: Continuous infusion of Propofol or remimazolam attenuated RPH but not acute pain or analgesic consumption after PEID, potentially lowering the risk of chronic pain.
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