ArticleFrontiers in medicine2025
Microneedle radiofrequency for skin rejuvenation: bridging image-derived metrics and photographic assessment.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Short-term efficacy and safety of 5MHz fractional microneedle radiofrequency for facial rejuvenation: a prospective study.Annals of medicine · 2026Trial
- A Retrospective Analysis of Radiofrequency Microneedling for Melasma Management in the Japanese Population.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To analyze the condition of the skin before and after microneedle radiofrequency (RF) treatment and to identify a series of cascade changes occurring within its structure. Additionally, to test whether regular home care modifies treatment effects and to corroborate objective changes with blinded Global Aesthetic Improvement Scale (GAIS) ratings. Materials and methods: A retrospective analysis was conducted using photographs of 38 women taken before and after a single microneedle RF treatment and 15 untreated controls. The images were captured using the Observ 520× device at baseline and 30 days post-procedure. Quantitative assessment of changes was performed with ImageJ software. The GAIS was used to evaluate visible changes in the photographs under blinding to group and time. The primary endpoint was the change score ( Results: Among the participants, at least 84.2% showed improvement in skin tone, reduction of pathological erythema, and increased skin hydration. GAIS distributions were bimodal (improvement 1-3 only in RF; no change/worsening 4-5 only in controls; Conclusion: Microneedle RF is an effective method for reducing wrinkles and improving image-derived pigmentation, vascular, and hydration metrics at 30 days, with a low complication rate. Regular home care functions as a clinically meaningful response amplifier, particularly for pigmentation- supporting protocolized post-procedure skincare to maximize outcomes. Findings are associative (non-randomized design); replication in randomized, adherence-controlled studies is warranted. Generalizability is limited (women aged 35-50, single center, predominantly Fitzpatrick I-III); extrapolation to men and darker phototypes (IV-VI) is not warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.