ArticleEuropean journal of case reports in internal medicine2025
Stem Cell Steal After Intravenous Iron: A Case of Transient Thrombocytopenia in Severe Iron Deficiency Anaemia.
Article in European journal of case reports in internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Iron-deficiency anaemia (IDA) commonly presents with reactive thrombocytosis. A less recognized, paradoxical decline in platelets may occur shortly after iron repletion. This phenomenon is most notably seen with intravenous (IV) formulations and termed the platelet steal effect. Case report: We describe a 68-year-old man with severe IDA (haemoglobin 6.6 g/dl; mean corpuscular volume 53.4 fl; ferritin 8.7 ng/ml; iron saturation 3.4%) who developed marked thrombocytopenia after initiation of IV iron. The platelet count trended down from 290 ×10 Conclusion: Transient thrombocytopenia following iron repletion is likely under-recognized. Awareness of its timing and benign course may prevent unnecessary testing or interruption of definitive IDA therapy. LEARNING POINTS: Transient thrombocytopenia may occur shortly after intravenous iron repletion in severe iron deficiency anaemia, despite the usual association with thrombocytosis.The "stem cell steal" phenomenon reflects a temporary shift of bone marrow progenitors toward erythropoiesis once iron becomes available.Recognizing this benign, self-limiting response prevents unnecessary investigations or interruption of essential iron therapy.
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