Correlation between concentrations of NAMPT and NMNAT1 and the risk of upper respiratory infections in the island reef.

backgroundThe frequent occurrence of respiratory diseases in the island reef environment of the navy severely affects the health of personnel and the combat effectiveness of the troops. Current common screening methods can only indicate whether there is an infection with pathogenic microorganisms but not the degree of disease progression. Therefore, it is necessary to identify simple-to-operate and cost-effective methods that indicate the degree of disease progression, based on traditional screening methods.

aimTo explores correlation between serum concentrations of nicotinamide phosphoribosyltransferase (NAMPT), nicotinamide nucleotide adenylyltransferase 1 (NMNAT1), and the risk of upper respiratory infections in the island reef envirsonment.

methodsA total of 600 cases of upper respiratory infections among naval officers and soldiers were included. Types of infection were confirmed through sputum culture combined with multiplex polymerase chain reaction. The serum concentrations of NAMPT and NMNAT1 were measured using ELISA, and infection severity was assessed using the pneumonia severity index (PSI). Statistical analysis was performed using nonparametric tests and Spearman correlation analysis.

resultsThe serum concentrations of NAMPT and NMNAT1 in high-risk group patients with PSI were significantly lower than those in the medium and low-risk groups (

conclusionConcentrations of NAMPT and NMNAT1 are closely related to severity of upper respiratory infections, and their common regulatory mechanisms provide new directions for development of broad-spectrum anti-infection strategies.