Evidence map›Paper›PMID 41377656›Full record

ArticleiScience2025

Impact of endogenous sonosensation on

Quanxiang Xian, Danni Li, Xinyi Zhao, Dongshuai Zhao, Yizhou Jiang, Jianing Jing, Xuandi Hou, Xiaohui Huang, Kin Fung Wong, Suresh Murugappan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Quanxiang XianDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Danni LiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Xinyi ZhaoDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Dongshuai ZhaoDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Yizhou JiangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Jianing JingDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Xuandi HouDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Xiaohui HuangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Kin Fung WongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Suresh MurugappanDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Zhihai QiuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.
Lei SunDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR 999077, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sonogenetics is a promising paradigm that uses non-invasive ultrasound to modulate neurons expressing sonosensitive proteins. However, the brain's varying endogenous sonosensitivity presents a challenge for its precise application. We first mapped this intrinsic sensitivity, identifying the somatosensory cortex as particularly responsive. Using an MscL-G22S-based approach in the somatosensory cortex, we found that ultrasound non-specifically activated both excitatory and inhibitory neurons in control mice, preventing behavioral output. In contrast, in MscL-expressing mice, ultrasound selectively activated excitatory neurons while suppressing inhibitory ones, thereby shifting the net neural response to successfully drive whisker movement. This effect was independent of auditory confounds or astrocytic involvement. Our study highlights that accounting for endogenous sonosensitivity is critical and demonstrates that optimized sonogenetic tools can achieve precise neuromodulation despite this inherent challenge.

Indexed as

Molecular neuroscienceSensory neuroscienceUltrasound technology

Identifiers

PMID41377656
PMCPMC12688701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.