ArticleNutrition research and practice2025
Effects of calcium, fucoidan and chitooligosaccharide supplementation on bone mineral density and calcium balance in ovariectomized rats.
Article in Nutrition research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesThis study examined the effect of calcium (Ca), fucoidan, and chitooligosaccharide supplementation alone and in combination on bone mineral density (BMD), bone metabolism, and Ca balance in ovariectomized (OVX) rats. MATERIALS/
methodsForty-eight female Wistar rats (6 weeks) were used in this study; among them, 40 rats were OVX, and the rest of the rats were sham-operated (sham). The sham group and one OVX group were fed a standard diet (AIN-96, Ca 0.5%), and the remaining OVX groups received either a fucoidan-supplemented diet (fucoidan 0.05%; OVX-Fu), a chitooligosaccharide-supplemented diet (chitooligosaccharide 0.5%; OVX-Chito), a seaweed Ca-supplemented diet (Ca 1.5%; OVX-Ca), or a fucoidan, chitooligosaccharide and seaweed Ca-supplemented diet (fucoidan 0.05%, chitooligosaccharide 0.5%, Ca 1.5%; OVX-CaFuChito) for 12 weeks.
resultsThe OVX-CaFuChito group had the highest feed intake, but had a significantly lower final body weight than the other groups in OVX rats. The Ca retention was significantly higher in the OVX-Ca and OVX-CaFuChito groups than in all the other groups (
conclusionThese results suggest that only the combined supplementation of Ca, fucoidan, and chitooligosaccharides may have a beneficial effect on preserving BMD along with suppressing postmenopausal weight gain.
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