ArticleFrontiers in nutrition2025
The association between magnesium levels and gout: evidence from Mendelian randomization, a Chinese cross-sectional study, and NHANES analysis.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Although the roles of micronutrients in human health are widely acknowledged, their specific associations with gout remain inadequately explored. This study integrates evidence from Mendelian randomization (MR), Chinese cross-sectional, and NHANES analyses to comprehensively investigate. Methods: The MR analysis was used to evaluate the potential causal associations between 15 trace elements (copper, calcium, iron, magnesium, potassium, selenium, zinc, carotenoids, folate, vitamin A, vitamin B12, vitamin B6, vitamin C, vitamin D, and vitamin E) and gout risk from the FinnGen database ( Results: Univariable MR identified calcium, magnesium, and vitamin B6 as associated with gout. Multivariable MR indicated that only higher magnesium levels causally reduced gout risk (OR = 0.630, 95% CI: 0.400-0.992, Discussion: This multifaceted study provides novel evidence supporting a protective role of magnesium against gout. The underlying mechanism may involve magnesium's influence on uric acid or its anti-inflammatory effects. These hypotheses need to be clarified by further experimental and clinical studies.
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