ArticleWorld journal of critical care medicine2025
Length of stay, duration of mechanical ventilation, mortality, and acute kidney injury in acute respiratory failure requiring endotracheal intubation.
Article in World journal of critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCritically ill patients often present on admission or develop acute respiratory failure requiring intubation and application of positive pressure ventilation during their hospital stay.
aimTo investigate and identify the epidemiological data, parameters associated with respiratory settings or the mechanics, and values related to arterial blood gases (ABGs) that are associated with outcomes in critically ill patients.
methodsA retrospective analysis of 131 patients [mean age, 67.3 years; mean acute physiology and chronic health evaluation (APACHE) score, 21.4] with acute respiratory failure requiring invasive mechanical ventilation was performed. The parameters that were statistically analyzed included demographic data, the presence of comorbidities, the presence of coronavirus disease 19 (COVID-19), the respiratory rate (RR), peak airway pressure (Ppeak), minute ventilation (MV), positive end-expiratory pressure, and the values related to ABGs. In order to facilitate the statistical analysis, patients were evaluated and compared in groups: Survivors (
resultsNon-survivors presented statistically significant differences in terms of being older in age, the presence of comorbidities, elevated APACHE score, medical (
conclusionAmong all investigated outcome measures, COVID-19, Ppeak, and RR were strongly associated with all the endpoints studied, suggesting that proper interventions involving the modifiable respiratory parameters Ppeak and RR could improve the overall outcome in these patients. A novel finding of this study was the relationship between RR and AKI, which is worthy of further investigation. Future studies may explore the clinical interpretation of these findings to improve outcomes in critically ill patients with acute respiratory failure.
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