ArticleFrontiers in psychiatry2025
Antidepressants and hypertensive disorders in pregnancy: a retrospective cohort analysis.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Second-trimester dyadic coping and risk of third-trimester depressive symptoms: development and internal validation of a prediction model.Frontiers in medicine · 2026Article
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6 authors.
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Abstract
Objective: This retrospective cohort study investigated relationships between antidepressant use in pregnancy and hypertensive disorders of pregnancy. Design/setting/sample: Observational cohort study examining births in an outer-metropolitan maternity hospital in Australia between 2008-2022. 75,308 births were examined. Methods: Logistic regression analysis considering covariates including maternal age, smoking, BMI, depression, anxiety, schizophrenia or bipolar disorder, gestational diabetes, pre-pregnancy diabetes. The antidepressant treatment cohort was compared with two groups: all births at this hospital within this time period, and a more closely matched depressed/anxious cohort not treated with antidepressants in pregnancy. The overall group of women taking antidepressants in pregnancy was also compared with women taking antihypertensive medications in pregnancy. Main outcome measures: Clinical diagnoses of hypertension, pre-eclampsia or eclampsia recorded in pregnancy, at birth or the immediate postpartum, as well as treatment with antihypertensive medication. Results: A statistically significant relationship ( Conclusions: This study supports existing research suggesting a strong relationship between antidepressant use in pregnancy and hypertensive disorders. Comparison with a depressed/anxious cohort reduces the risk that these underlying conditions could contribute to this finding.
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