ArticleAnnals of medicine and surgery (2012)2025
Expression and clinical significance of SIRT2 in gastric cancer: a retrospective study.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Metabolic Signaling Meets Epigenetic Regulation: How Protein Lactylation Remodels the Tumor Immune Microenvironment in Gastric Cancer.Current issues in molecular biology · 2026Review
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Authors and funding
6 authors.
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Abstract
Background: Sirtuin 2 (SIRT2), a member of the histone deacetylase family, plays a critical role in various types of tumors. However, its role in the progression of gastric cancer (GC) remains unclear. This study aimed to investigate the function and clinical relevance of SIRT2 in GC progression. Methods: We collected 71 GC tissues, and 35 cases were paired with adjacent normal tissue from the same patient at our hospital. SIRT2 expression levels were evaluated using immunohistochemistry (IHC) and bioinformatics analysis. Correlation between SIRT2 expression and various clinicopathological features and immune cell infiltration were also analyzed. Results: IHC analysis revealed significantly elevated SIRT2 expression in GC tissues compared with that in adjacent normal tissues ( Conclusion: SIRT2 is upregulated in GC tissues and is associated with poor prognosis. It may serve as a promising biomarker for predicting GC progression and evaluating patient outcomes.
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