ArticleAnnals of medicine and surgery (2012)2025
Cerebrospinal fluid volume: the overlooked determinant in brain and spinal stroke.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
Emerging evidence suggests that reduced cerebrospinal fluid (CSF) volume may contribute to the onset and progression of both brain and spinal strokes. Traditionally under recognized, low CSF states can alter cerebral perfusion, compromise venous compliance, and exert mechanical strain on critical neural structures. This commentary integrates clinical observations, imaging findings, and biomechanical data to highlight the role of CSF depletion in stroke pathophysiology. Recognizing this mechanism may refine current models of cerebrovascular disease and inform novel strategies for prevention and management.
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