ReviewAnnals of medicine and surgery (2012)2025
From menses to ovulation: the immunomodulatory role of monocyte cytokines in menstrual cycle physiology and reproductive health - a narrative review.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocytes, as essential components of the immune system, play a pivotal role in regulating immune responses throughout the menstrual cycle. Their cytokine secretion is integral to immune modulation, influencing processes like endometrial remodeling, ovulation, and implantation. Cytokines such as interleukins, tumor necrosis factor (TNF), and growth factors secreted by monocytes help maintain a delicate balance between inflammation and immune tolerance, crucial for reproductive health. This balance facilitates both tissue repair and immune protection, ensuring proper function of the reproductive organs during the menstrual cycle. Dysregulation in monocyte cytokine secretion can contribute to a range of reproductive disorders, including endometriosis, polycystic ovary syndrome, and recurrent pregnancy loss. An overproduction of pro-inflammatory cytokines, such as TNF-α and interleukin-6, may lead to chronic inflammation, tissue damage, and impaired fertility. Conversely, inadequate secretion of anti-inflammatory cytokines can hinder the immune tolerance necessary for embryo implantation, potentially leading to complications like miscarriage. This review explores the pivotal role of monocytes and their cytokine secretion in maintaining reproductive health and their contribution to reproductive disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.