ArticleAnnals of medicine and surgery (2012)2025
Transdermal diclofenac versus oral paracetamol-ibuprofen combination for postoperative pain following surgical extraction of mandibular third molar: a randomized controlled trial.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
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Abstract
Background: Postoperative pain management following surgical extraction of mandibular third molars require effective analgesic options with favorable safety profiles. This study compares the analgesic efficacy and side effect profiles of a transdermal diclofenac patch versus oral combination of paracetamol and ibuprofen. Materials and methods: Total of 108 patients indicated for surgical extraction of mandibular third molars were randomized into two groups: Group-A ( Results: Both groups showed significant pain scores reduction over time. Mean NRS scores at 12, 24 and 72 hours were 3.06, 1.15, and 0.69 (Group-A) vs. 3.46, 1.22, and 0.67 (Group-B) respectively with no statistically significant differences in pain scores between two groups at any time. However, the incidence of side effects, particularly gastric irritation, was significantly higher in Group-A compared to Group-B. Conclusion: Both the transdermal diclofenac patch and the oral combination of paracetamol and ibuprofen are effective in managing postoperative pain following mandibular third molar extraction. However, the transdermal diclofenac patch has significantly fewer gastrointestinal side effects, making it a preferable option for patients at risk of gastric irritation.
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