ArticleAnnals of medicine and surgery (2012)2025
Post-COVID-19 shifts in granulomatosis with polyangiitis: epidemiology, clinical features, and predictors in Iran.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Granulomatosis with polyangiitis (GPA) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by necrotizing granulomatous inflammation and small- to medium-vessel vasculitis. The COVID-19 pandemic has raised interest in its potential to trigger autoimmune diseases like GPA. This retrospective study investigates changes in GPA frequency, clinical features, and serological patterns before and after the COVID-19 pandemic. Methods: This retrospective study analyzed 72 patients with GPA at one of the most referral hospitals (2016-2024), divided into pre-COVID ( Results: A total of 72 patients with GPA were analyzed, including 27 diagnosed pre-COVID-19 and 45 post-COVID-19. The post-COVID-19 cohort was significantly younger (mean age 37.75 ± 10.38 vs. 50.66 ± 12.76 years, Conclusion: This study reveals a higher frequency of GPA and a younger age at onset post-COVID-19. Predictors of post-COVID-19 GPA included younger age, male sex, and pulmonary involvement. SARS-CoV-2 may trigger autoimmune activation, but no link with vaccination was found. GPA clinical features remained consistent, warranting ongoing monitoring and research into COVID-19's autoimmune effects.
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