Interplay of multiple neurological conditions - the first case of neurological Whipple's disease in Syria: a case report.

Nizaar Adnan Aloqla, Mohammad Basheer Alameer, Jameel Soqia, Aman Nakawa, Ghassan Hamzeh

Abstract readCase Reports

In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Deciphering whipple's disease complexity.Clinical and experimental medicine · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nizaar Adnan AloqlaFaculty of Medicine, Damascus University, Damascus, Syria.ORCID https://orcid.org/0009-0009-1508-4650

Mohammad Basheer AlameerFaculty of Medicine, Damascus University, Damascus, Syria.ORCID https://orcid.org/0009-0001-7156-567X

Jameel SoqiaFaculty of Medicine, Damascus University, Damascus, Syria.

Aman NakawaDamascus University, Assad University Hospital, Syria, department of neurology, Damascus, Syria.

Ghassan HamzehFaculty of Medicine, Damascus University, Damascus, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction and importance: Whipple disease is a rare systemic infection caused by the bacterium Case presentation: We report a case of a 35-year-old Syrian female with neurological Whipple disease presenting with recurrent tonic-clonic seizures, cognitive disturbances, and communicating hydrocephalus, requiring a ventriculoperitoneal shunt. Her complex clinical course included pyomeningitis associated with shunt infection. Diagnostic imaging and cerebrospinal fluid (CSF) analyses confirmed CNS involvement. Management included antibiotic therapy targeting CNS infection and antiepileptics. Clinical discussion: There were multiple differential diagnoses for this patient, as well as the interplay of multiple conditions as a result of Whipple disease or medical intervention, which shows the importance of keeping every possibility in mind. Moreover, giving proper instructions to the patient can help reduce complications. Conclusion: The successful treatment and ongoing follow-up demonstrate the importance of a multidisciplinary approach in addressing the diverse manifestations of neurological conditions.

Indexed as

biopsycentral nervous system (CNS)PCR testingTropheryma whippeliiWhipple disease

Identifiers

PMID41377310

DOI10.1097/MS9.0000000000003531

PMCPMC12688743

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.