ReviewAnnals of medicine and surgery (2012)2025
Optimizing endocrine adjuvant therapy in HR+/HER2- breast cancer: supplemental strategies and innovations.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Endocrine therapy (ET) is a cornerstone in adjuvant therapy for hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-) breast cancer. However, recent research challenges the conventional 5-year adjuvant therapy duration. Patients with T1N0M0 HR+/HER2- breast cancer face a 13% risk of distant recurrence after 5 years of endocrine treatment. This risk increases to 34% over two decades for patients with 4-9 lymph node metastases. Thus, it is important to consider supplementary treatments for T1N0M0 HR+/HER2- breast cancer patients, particularly those with additional high-risk features such as young age, high tumor grade, or adverse genomic profile. We summarize intensive treatment methods for T1N0M0 HR+/HER2- breast cancer patients, which extend beyond the standard 5-year tamoxifen (TAM)-based adjuvant ET. These methods include intensive ET, poly(ADP-ribose) polymerase (PARP) inhibitors, other targeted therapies, antibody-drug conjugates, oral chemotherapy, immunotherapy, and enhanced prevention of bone metastasis. This review provides a foundation for developing personalized adjuvant treatment strategies for patients with T1N0M0 HR+/HER2- breast cancer.
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