Protective strategies and therapeutic interventions for ischemia-reperfusion injury: potential applications in normothermic machine perfusion.

Qingze Meng, Jiahao Li, Jitian He, Ruilin Cai, Xiaoshun He, Zhao Qiang

Abstract readReview

In one paragraph

Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qingze MengOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Jiahao LiOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Jitian HeOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Ruilin CaiOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Xiaoshun HeOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Zhao QiangOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in perfusion technology have positioned normothermic machine perfusion (NMP) as a promising alternative. However, the unavoidable occurrence of ischemia-reperfusion injury (IRI) during perfusion remains a critical barrier to enhancing postoperative outcomes and graft survival. This review systematically examines current pharmacological strategies to mitigate IRI in NMP, targeting key pathological mechanisms including oxidative stress, inflammatory cascades, apoptotic pathways, and endothelial dysfunction. We highlight promising therapeutic agents that have demonstrated efficacy in animal models, preclinical experiments, and

Indexed as

anti-apoptotic drugsanti-endothelial dysfunction drugsanti-inflammatory drugsantioxidant drugsischemia-reperfusion injuryliver preservationnormothermic machine perfusiontherapeutic strategies

Identifiers

PMID41377275

DOI10.1097/MS9.0000000000004184

PMCPMC12688927

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.