ArticleAnnals of medicine and surgery (2012)2025
Targeting aerobic glycolysis by quercetin inhibits acute monocytic leukemia SHI-1 cells.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Quercetin (Que) exhibits antitumor properties. This study aims to investigate whether Que inhibits the proliferation of acute monocytic leukemia SHI-1 cells by suppressing glycolysis and regulating energy metabolism. Methods: SHI-1 cells were treated with Que. Cell viability, colony-forming ability, and contents of pyruvate, lactate, and ATP of SHI-1 cells were measured. Immunofluorescence staining analyzed the expression of myelocytomatosis oncogene (c-Myc), glucose transporter 1 (GLUT1), PKM2, and p-AMP-activated protein kinase (AMPK). Western blotting and RT-qPCR detected the levels of c-Myc, GLUT1, hexokinase (HK2), PKM2, lactate dehydrogenase, pyruvate dehydrogenase kinase 2, AMPK, mammalian target of rapamycin (mTOR), and p-mTOR in SHI-1 cells. An acute monocytic leukemia model was established in BALB/c nude male mice and administered Que by gavage. Results: Que-suppressed proliferation and reduced pyruvate, lactate, and ATP production in SHI-1 cells. The inhibitory effects of Que on cell viability were reversed by pyruvate. Que-inhibited glycolysis-related proteins and mRNAs in SHI-1 cells. It also declined phosphorylation of AMPK and mTOR. Conclusion: This study demonstrates that Que exerts antileukemia effects by inhibiting proliferation, glycolysis, and energy metabolism in acute monocytic leukemia cells.
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