ArticleAnnals of medicine and surgery (2012)2025
Postoperative seizure prophylaxis after craniotomy: a current evidence and ongoing controversy.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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3 authors.
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Abstract
Postoperative seizures are a recognized complication following intracranial surgery, with implications for neurologic recovery, length of stay, and quality of life. Despite decades of investigation, the role of routine seizure prophylaxis after craniotomy remains debated. Early trials supported short-term phenytoin use, while recent evidence and guidelines question its necessity in seizure-naïve patients. This review summarizes current data regarding the incidence, risk factors, and prevention of post-craniotomy seizures, with emphasis on the comparative efficacy of antiepileptic agents and the appropriate duration of prophylaxis. Levetiracetam has largely replaced phenytoin in modern practice due to improved tolerability, though neither has shown clear superiority in preventing late seizures. Most data support selective, rather than routine, prophylaxis limited to the immediate postoperative period in high-risk populations. Future work should focus on individualized risk stratification and standardized institutional protocols.
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